Effects of Alcohol in Different Doses on Cerebral Purkinje Cells

Abstract

According to information in the literature, different departments of the brain show selective sensitivity to alcohol [5,6,7]. Although Purkinje cells (PH) of the cerebellum play a major role in the control of movements and show high reactivity to various types of afferent stimuli, data on the effects of alcohol on these cells are scarce and conflicting. In addition, the movement disorders caused by alcohol are similar to the coordination disorders of patients with cerebellar ataxia, but the available clinical material does not allow to detect early morphological changes of nerve cells of the cerebellar cortex during alcohol intoxication [4,8,9]. Our previous studies [1,2,3,10] revealed changes in the Purkinje cells of the cerebellum under the influence of a small dose of ethanol and the cumulative effect of repeated administration of alcohol.